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Sartorius Introduces Crossflow Filtration System

Ideal for scaling studies and low volume ultra- and diafiltration operations

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By: Tim Wright

Editor-in-Chief, Contract Pharma

Sartorius Stedim Biotech has launched the Sartoflow Smart benchtop crossflow system for optimized ultra- and diafiltration applications. It can be used in many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins. The system is suitable for flexible use in laboratory environments for process development and clinical trials as well as for cGMP environments.

The brand new system is equipped with a low shear 4-piston membrane pump that enables highest product yields to be achieved. In addition the pump provides a wide range of flow rates allowing to choose between membrane surface areas from 50 cm² to as much as 0.14 m².

The crossflow system is supplied with Sartorius’ DCU-4 control unit, which, when combined with the company’s BioPAT SCADA, MFCS-4 software, provides data logging and export. Its touchscreen offers instant access to all critical process parameters and displays control and alarm functions. A logbook function stores alarms, set points and user logs.

“Sartoflow Smart is a milestone development in the landscape of small crossflow systems,” said Marc Jenke, expert for benchtop crossflow filtration systems, Sartorius Stedim Biotech. “It combines outstanding technology with options that are normally only available with process systems. With an exceptionally wide working range of membrane surface areas, the system is the perfect tool for both R&D optimization trials and cGMP production.”

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